POLR3C anticorps (AA 1-534)

N° du produit ABIN7150458

L’anticorps Lapin Polyclonal anti-POLR3C a été validé pour WB et ELISA. Il convient pour détecter POLR3C dans des échantillons de Humain.

Aperçu rapide pour POLR3C anticorps (AA 1-534) (ABIN7150458)

Antigène: POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp POLR3C est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-POLR3C anticorps

Épitope: AA 1-534

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human DNA-directed RNA polymerase III subunit RPC3 protein (1-534AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur POLR3C

Antigène: POLR3C (Polymerase (RNA) III (DNA Directed) Polypeptide C (62kD) (POLR3C))

Autre désignation: POLR3C

Sujet:

Background: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Aliases: DNA directed III 62 kDa polypeptide antibody, DNA-directed RNA polymerase III subunit C antibody, DNA-directed RNA polymerase III subunit rpc3 antibody, POLR3C antibody, Polymerase (RNA) III (DNA directed) polypeptide C (62kD) antibody, RNA polymerase C subunit 3 antibody, RNA polymerase III 62 kDa subunit antibody, RNA polymerase III C62 subunit antibody, RNA polymerase III subunit C3 antibody, RPC3 antibody, RPC3_HUMAN antibody, RPC62 antibody

UniProt: Q9BUI4