NDEL1 anticorps (pThr219) (Biotin)

N° du produit ABIN710833

Cet anticorps Lapin Polyclonal détecte spécifiquement NDEL1 dans ELISA, IHC (p) et IHC (fro). Il présente une réactivité envers Rat.

Aperçu rapide pour NDEL1 anticorps (pThr219) (Biotin) (ABIN710833)

Antigène: NDEL1 (NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 (NDEL1))

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NDEL1 est conjugé à/à la Biotin

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Détail du produit anti-NDEL1 anticorps (Biotin)

Épitope: pThr219

Réactivité croisée: Rat

Homologie: Human,Mouse,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human NDEL1 around the phosphorylation site of Thr219

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur NDEL1

Antigène: NDEL1 (NudE Nuclear Distribution E Homolog (A. Nidulans)-Like 1 (NDEL1))

Autre désignation: NDEL1

Sujet:

Synonyms: NDEL1phospho T219, Nudelphospho T219, A. nidulans, DKFZp451M0318, ENDOOLIGOPEPTIDASE A, EOPA, MITAP 1, MITAP1, Mitosin associated protein 1, Mitosin associated protein MITAP1, Mitosin-associated protein 1, Ndel 1, Ndel1, NDEL1_HUMAN, Nuclear distribution gene E like homolog 1, Nuclear distribution protein nudE like 1, Nuclear distribution protein nudE-like 1, NUDE like protein, NudE nuclear distribution gene E homolog like 1 A. nidulans, NudE nuclear distribution gene E homolog like 1, NUDEL, Protein Nudel.

Background: Nudel is important for normal cortical development. It is invovled in microtubule organization, nuclear translocation, and neuronal positioning in concert with various other factors (including Lis1, Pafah1b1, Pahfah1b2, dynein, dynorphin A and cdk5). Western blot analysis of mouse tissues shows abundant expression of Nudel in brain and testis, and much lower expression in heart, liver, kidney, and skeletal muscle. In fractionated rat brain, Nudel and Lis1 are both found in fractions enriched for postsynaptic density proteins. Immunostaining of embryonic day 18 mouse brain sections revealed staining of migrating neurons and thalamocortical axons of the intermediate zone of the developing cerebral cortex, as well as several other developing brain regions. The deduced protein contains 345 amino acids and has a calculated molecular mass of 38.4 kDa. It has a coiled coil motif (residues 19 to 201), followed by several potential phosphorylation sites for casein kinase II, protein kinase C or CDK5. Nudel shares about 50 % identity with mouse and human NUDE proteins.

ID gène: 81565

Pathways: Regulation of Cell Size