DMRT1 anticorps (AA 195-363)

N° du produit ABIN7150637

Détail du produit anti-DMRT1 anticorps

Antigène: DMRT1 (Doublesex and Mab-3 Related Transcription Factor 1 (DMRT1))

Épitope: AA 195-363

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DMRT1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Doublesex- and mab-3-related transcription factor 1 protein (195-363AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DMRT1

Antigène: DMRT1 (Doublesex and Mab-3 Related Transcription Factor 1 (DMRT1))

Autre désignation: DMRT1 (DMRT1 Produits)

Synonymes: anticorps DMT1, anticorps DMRT1, anticorps zgc:136676, anticorps dmrt1, anticorps dmrt1-alpha, anticorps dmt1, anticorps dmrt1-beta, anticorps xdmrt1, anticorps doublesex and mab-3 related transcription factor 1, anticorps doublesex and mab-3 related transcription factor 1 L homeolog, anticorps doublesex and mab-3 related transcription factor 1 S homeolog, anticorps DMRT1, anticorps Dmrt1, anticorps dmrt1, anticorps dmrt1.L, anticorps dmrt1.S

Sujet:

Background: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).

Aliases: CT154 antibody, DM domain expressed in testis 1 antibody, DM domain expressed in testis protein 1 antibody, DM domain gene expressed in testis antibody, DMRT 1 antibody, dmrt1 antibody, DMRT1_HUMAN antibody, DMT 1 antibody, DMT1 antibody, Doublesex and mab 3 related transcription factor 1 antibody, Doublesex- and mab-3-related transcription factor 1 antibody

UniProt: Q9Y5R6