CBLC anticorps (AA 245-474)

N° du produit ABIN7151000

Détail du produit anti-CBLC anticorps

Antigène: CBLC (Cbl proto-oncogene C (CBLC))

Épitope: AA 245-474

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CBLC est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human E3 ubiquitin-protein ligase CBL-C protein (245-474AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CBLC

Antigène: CBLC (Cbl proto-oncogene C (CBLC))

Autre désignation: CBLC (CBLC Produits)

Synonymes: anticorps CBL-3, anticorps CBL-SL, anticorps RNF57, anticorps Cbl proto-oncogene C, anticorps CBLC, anticorps Cblc

Sujet:

Background: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction, upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at \\\'Tyr-419\\\'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation, CD2AP converts it from an inhibitor to a promoter of RET degradation, the function limits the potency of GDNF on neuronal survival.

Aliases: CBLC antibody, CBL3 antibody, RNF57E3 ubiquitin-protein ligase CBL-C antibody, EC 2.3.2.27 antibody, RING finger protein 57 antibody, RING-type E3 ubiquitin transferase CBL-C antibody, SH3-binding protein CBL-3 antibody, SH3-binding protein CBL-C antibody, Signal transduction protein CBL-C antibody

UniProt: Q9ULV8

Pathways: EGFR Signaling Pathway