SIAH2 anticorps (AA 1-72) (FITC)

N° du produit ABIN7151220

L’anticorps Lapin Polyclonal anti-SIAH2 a été validé pour . Il convient pour détecter SIAH2 dans des échantillons de Humain.

Aperçu rapide pour SIAH2 anticorps (AA 1-72) (FITC) (ABIN7151220)

Antigène: SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIAH2 est conjugé à/à la FITC

Application: Veuillez nous consulter SVP

Détail du produit anti-SIAH2 anticorps (FITC)

Épitope: AA 1-72

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human E3 ubiquitin-protein ligase SIAH2 protein (1-72AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SIAH2

Antigène: SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))

Autre désignation: SIAH2

Sujet:

Background: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia. It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes. Has some overlapping function with SIAH1. Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not. Promotes monoubiquitination of SNCA.

Aliases: E3 ubiquitin-protein ligase Siah2 antibody, hSiah2 antibody, Seven in absentia homolog 2 antibody, Siah E3 ubiquitin protein ligase 2 antibody, Siah-2 antibody, siah2 antibody, SIAH2_HUMAN antibody, Ubiquitin Ligase Siah2 antibody

UniProt: O43255