PHD1 anticorps (AA 283-407) (HRP)

N° du produit ABIN7151447

Cet anticorps Lapin Polyclonal détecte spécifiquement PHD1 dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour PHD1 anticorps (AA 283-407) (HRP) (ABIN7151447)

Antigène: PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PHD1 est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-PHD1 anticorps (HRP)

Épitope: AA 283-407

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Egl nine homolog 2 protein (283-407AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PHD1

Antigène: PHD1 (EGLN2) (Egl-9 Family Hypoxia Inducible Factor 2 (EGLN2))

Autre désignation: EGLN2

Sujet:

Background: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle. Also regulates susceptibility to normoxic oxidative neuronal death. Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation. Hydroxylates IKBKB, mediating NF-kappaB activation in hypoxic conditions. Target proteins are preferencially recognized via a LXXLAP motif.

Aliases: DKFZp434E026 antibody, EGL nine (C.elegans) homolog 2 antibody, Egl nine homolog 2 (C. elegans) antibody, Egl nine homolog 2 antibody, EGLN 2 antibody, EGLN2 antibody, EGLN2_HUMAN antibody, EIT 6 antibody, EIT6 antibody, Estrogen-induced tag 6 antibody, HIF P4H 1 antibody, HIF PH1 antibody, HIF prolyl hydroxylase 1 antibody, HIF-PH1 antibody, HIF-prolyl hydroxylase 1 antibody, HIFPH 1 antibody, HIFPH1 antibody, HPH 3 antibody, HPH-1 antibody, HPH-3 antibody, HPH3 antibody, Hypoxia inducible factor prolyl hydroxylase 1 antibody, Hypoxia-inducible factor prolyl hydroxylase 1 antibody, P4H1 antibody, PHD 1 antibody, PhD1 antibody, prolyl hydroxylase domain containing protein 1 antibody, Prolyl hydroxylase domain-containing protein 1 antibody

UniProt: Q96KS0

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Cell RedoxHomeostasis