EIF4A3 anticorps (AA 6-166) (HRP)

N° du produit ABIN7152117

L’anticorps Lapin Polyclonal anti-EIF4A3 a été validé pour ELISA. Il convient pour détecter EIF4A3 dans des échantillons de Humain.

Aperçu rapide pour EIF4A3 anticorps (AA 6-166) (HRP) (ABIN7152117)

Antigène: EIF4A3 (Eukaryotic Translation Initiation Factor 4A3 (EIF4A3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF4A3 est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-EIF4A3 anticorps (HRP)

Épitope: AA 6-166

Fonction: EIF4A3 Antibody, HRP conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Eukaryotic initiation factor 4A-III protein (6-166AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EIF4A3

Antigène: EIF4A3 (Eukaryotic Translation Initiation Factor 4A3 (EIF4A3))

Autre désignation: EIF4A3

Sujet:

Background: ATP-dependent RNA helicase. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the function is different from the established EJC assembly. Involved in craniofacial development.

Aliases: ATP-dependent RNA helicase DDX48 antibody, ATP-dependent RNA helicase eIF4A-3 antibody, DDX48 antibody, DEAD box protein 48 antibody, eIF-4A-III antibody, eIF4A-III antibody, EIF4A3 antibody, eIF4AIII antibody, Eukaryotic initiation factor 4A-III antibody, Eukaryotic initiation factor 4A-like NUK-34 antibody, Eukaryotic translation initiation factor 4A isoform 3 antibody, hNMP 265 antibody, IF4A3_HUMAN antibody, NMP 265 antibody, NMP265 antibody, Nuclear matrix protein 265 antibody, NUK34 antibody

UniProt: P38919