EIF3E anticorps (AA 1-445)

N° du produit ABIN7152153

L’anticorps Lapin Polyclonal anti-EIF3E a été validé pour ELISA et IHC. Il convient pour détecter EIF3E dans des échantillons de Humain.

Aperçu rapide pour EIF3E anticorps (AA 1-445) (ABIN7152153)

Antigène: EIF3E (Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EIF3E est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Détail du produit anti-EIF3E anticorps

Épitope: AA 1-445

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Eukaryotic translation initiation factor 3 subunit E protein (1-445AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EIF3E

Antigène: EIF3E (Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E))

Autre désignation: EIF3E

Sujet:

Background: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. Required for nonsense-mediated mRNA decay (NMD), may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.

Aliases: eIF-3 p48 antibody, eIF3e antibody, EIF3E_HUMAN antibody, EIF3S6 antibody, eIFe antibody, Eukaryotic translation initiation factor 3 subunit 6 antibody, Eukaryotic translation initiation factor 3 subunit E antibody, eukaryotic translation initiation factor 3, subunit 6 (48kD) antibody, INT6 antibody, mammary tumor-associated protein INT6 antibody, murine mammary tumor integration site 6 (oncogene homolog) antibody, Viral integration site protein INT-6 homolog antibody

UniProt: P60228

Pathways: Ribonucleoprotein Complex Subunit Organization, Hepatitis C