EXOSC1 anticorps (AA 9-195) (HRP)

N° du produit ABIN7152284

Détail du produit anti-EXOSC1 anticorps (HRP)

Antigène: EXOSC1 (Exosome Component 1 (EXOSC1))

Épitope: AA 9-195

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EXOSC1 est conjugé à/à la HRP

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Exosome complex component CSL4 protein (9-195AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EXOSC1

Antigène: EXOSC1 (Exosome Component 1 (EXOSC1))

Autre désignation: EXOSC1 (EXOSC1 Produits)

Synonymes: anticorps MGC86284, anticorps CGI-108, anticorps CSL4, anticorps Csl4p, anticorps SKI4, anticorps Ski4p, anticorps hCsl4p, anticorps p13, anticorps 2610035C18Rik, anticorps 2610104C07Rik, anticorps 2610312F07Rik, anticorps AI447561, anticorps exosome component 1, anticorps exosome component 1 L homeolog, anticorps EXOSC1, anticorps exosc1.L, anticorps exosc1, anticorps PTRG_05845, anticorps Exosc1

Sujet:

Background: Non-catalytic component of the RNA exosome complex which has 3\'->5\' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding \'pervasive\' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3\' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.

Aliases: 3'-5' exoribonuclease CSL4 homolog antibody, CGI 108 antibody, CGI-108 antibody, CSL4 antibody, CSL4 exosomal core protein homolog antibody, CSL4, S. cerevisiae, homolog of antibody, Csl4p antibody, EXOS1_HUMAN antibody, Exosc1 antibody, Exosomal core protein CSL4 antibody, Exosome complex component csl4 antibody, Exosome component 1 antibody, hCsl4p antibody, Homolog of yeast exosomal core protein CSL4 antibody, p13 antibody, RP11-452K12.9 antibody, SKI4 antibody, Ski4p antibody

UniProt: Q9Y3B2