EXOSC1 anticorps (AA 587-762) (HRP)

N° du produit ABIN7152304

Cet anticorps anti-EXOSC1 est un anticorps Lapin Polyclonal détectant EXOSC1 dans ELISA. Adapté pour Humain.

Aperçu rapide pour EXOSC1 anticorps (AA 587-762) (HRP) (ABIN7152304)

Antigène: EXOSC1 (Exosome Component 1 (EXOSC1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EXOSC1 est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-EXOSC1 anticorps (HRP)

Épitope: AA 587-762

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Exosome component 10 protein (587-762AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EXOSC1

Antigène: EXOSC1 (Exosome Component 1 (EXOSC1))

Autre désignation: EXOSC1

Sujet:

Background: Putative catalytic component of the RNA exosome complex which has 3\'->5\' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding \'pervasive\' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3\' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC10 has 3\'-5\' exonuclease activity (By similarity). EXOSC10 is required for nucleolar localization of C1D and probably mediates the association of SKIV2L2, C1D and MPP6 wth the RNA exosome involved in the maturation of 5.8S rRNA.

Aliases: Autoantigen PM/Scl 2 antibody, Exosc10 antibody, Exosome component 10 antibody, EXOSX_HUMAN antibody, P100 polymyositis scleroderma overlap syndrome associated autoantigen antibody, P100 polymyositis-scleroderma overlap syndrome-associated autoantigen antibody, p2 antibody, p3 antibody, p4 antibody, PM Scl antibody, PM/Scl 100 antibody, PM/Scl-100 antibody, PMSCL antibody, PMSCL2 antibody, Polymyositis/scleroderma autoantigen 100 kDa antibody, Polymyositis/scleroderma autoantigen 2 100 kDa antibody, Polymyositis/scleroderma autoantigen 2 antibody, RRP6 antibody, Rrp6p antibody

UniProt: Q01780