XPO1 anticorps (AA 625-845) (HRP)

N° du produit ABIN7152320

Cet anticorps Lapin Polyclonal détecte spécifiquement XPO1 dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour XPO1 anticorps (AA 625-845) (HRP) (ABIN7152320)

Antigène: XPO1 (Exportin 1 (XPO1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp XPO1 est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-XPO1 anticorps (HRP)

Épitope: AA 625-845

Fonction: XPO1 Antibody, HRP conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Exportin-1 protein (625-845AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur XPO1

Antigène: XPO1 (Exportin 1 (XPO1))

Autre désignation: XPO1

Sujet:

Background: Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.

Aliases: Chromosome region maintenance 1 protein homolog antibody, CRM 1 antibody, CRM1 homolog antibody, DKFZp686B1823 antibody, emb antibody, Exp 1 antibody, Exp1 antibody, Exportin 1 antibody, Exportin-1 antibody, Exportin1 antibody, XPO 1 antibody, xpo1 antibody, XPO1_HUMAN antibody

UniProt: O14980

Pathways: M Phase