EYA1 anticorps (AA 168-321) (Biotin)

N° du produit ABIN7152356

Cet anticorps Lapin Polyclonal détecte spécifiquement EYA1 dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour EYA1 anticorps (AA 168-321) (Biotin) (ABIN7152356)

Antigène: EYA1 (Eyes Absent Homolog 1 (EYA1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EYA1 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-EYA1 anticorps (Biotin)

Épitope: AA 168-321

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Eyes absent homolog 1 protein (168-321AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EYA1

Antigène: EYA1 (Eyes Absent Homolog 1 (EYA1))

Autre désignation: EYA1

Sujet:

Background: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (By similarity). Tyrosine phosphatase that dephosphorylates \'Tyr-142\' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. \'Tyr-142\' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19234442). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro) (By similarity). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears (By similarity). Together with SIX1, it plays an important role in hypaxial muscle development, in this it is functionally redundant with EYA2 (By similarity).

Aliases: BOP antibody, BOR antibody, BOS1 antibody, EYA transcriptional coactivator and phosphatase 1 antibody, Eya1 antibody, EYA1_HUMAN antibody, Eyes absent 1 antibody, Eyes absent 1 homolog antibody, Eyes absent homolog 1 (Drosophila) antibody, Eyes absent homolog 1 antibody, Eyes absent homolog1 antibody, MGC141875 antibody, OFC1 antibody

UniProt: Q99502

Pathways: Sensory Perception of Sound, Positive Regulation of Response to DNA Damage Stimulus