EYA3 anticorps (AA 1-300)

N° du produit ABIN7152363

L’anticorps Lapin Polyclonal anti-EYA3 a été validé pour WB, IHC et ELISA. Il convient pour détecter EYA3 dans des échantillons de Humain.

Aperçu rapide pour EYA3 anticorps (AA 1-300) (ABIN7152363)

Antigène: EYA3 (Eyes Absent Homolog 3 (EYA3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EYA3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-EYA3 anticorps

Épitope: AA 1-300

Fonction: EYA3 Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Eyes absent homolog 3 protein (1-300AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EYA3

Antigène: EYA3 (Eyes Absent Homolog 3 (EYA3))

Autre désignation: EYA3

Sujet:

Background: Tyrosine phosphatase that specifically dephosphorylates \\\'Tyr-142\\\' of histone H2AX (H2AXY142ph). \\\'Tyr-142\\\' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye.

Aliases: AI844637 antibody, DKFZp686C132 antibody, EYA3 antibody, EYA3_HUMAN antibody, Eyes absent 3 antibody, Eyes absent 3 homolog (Drosophila) antibody, Eyes absent homolog 3 antibody, OTTMUSP00000010370 antibody, RP11-460I13.4 antibody, RP23-442A20.1 antibody

UniProt: Q99504

Pathways: Positive Regulation of Response to DNA Damage Stimulus