FBXO9 anticorps (AA 13-111) (Biotin)

N° du produit ABIN7152452

Cet anticorps Lapin Polyclonal détecte spécifiquement FBXO9 dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour FBXO9 anticorps (AA 13-111) (Biotin) (ABIN7152452)

Antigène: FBXO9 (F-Box Protein 9 (FBXO9))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FBXO9 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-FBXO9 anticorps (Biotin)

Épitope: AA 13-111

Fonction: FBXO9 Antibody, Biotin conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human F-box only protein 9 protein (13-111AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FBXO9

Antigène: FBXO9 (F-Box Protein 9 (FBXO9))

Autre désignation: FBXO9

Sujet:

Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.

Aliases: Cross-immune reaction antigen 1 antibody, dJ341E18.2 antibody, DKFZp434C0118 antibody, F-box only protein 9 antibody, Fbp24 antibody, FBX09 antibody, FBX9 antibody, FBX9_HUMAN antibody, Fbxo9 antibody, KIAA0936 antibody, NY REN 57 antibody, OTTHUMP00000016628 antibody, OTTHUMP00000016629 antibody, OTTHUMP00000214588 antibody, Renal carcinoma antigen NY-REN-57 antibody, VCIA1 antibody

UniProt: Q9UK97