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FBXW5 anticorps (AA 265-494) (Biotin)

FBXW5 Reactivité: Humain ELISA Hôte: Lapin Polyclonal Biotin
N° du produit ABIN7152506
  • Antigène Voir toutes FBXW5 Anticorps
    FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))
    Épitope
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    AA 265-494
    Reactivité
    • 33
    • 17
    • 17
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 31
    • 2
    Lapin
    Clonalité
    • 33
    Polyclonal
    Conjugué
    • 11
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp FBXW5 est conjugé à/à la Biotin
    Application
    • 30
    • 13
    • 10
    • 4
    • 2
    • 1
    ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human F-box/WD repeat-containing protein 5 protein (265-494AA)
    Isotype
    IgG
    Top Product
    Discover our top product FBXW5 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    FBXW5 (F-Box and WD Repeat Domain Containing 5 (FBXW5))
    Autre désignation
    FBXW5 (FBXW5 Produits)
    Synonymes
    anticorps Fbw5, anticorps AI159739, anticorps F-box and WD repeat domain containing 5, anticorps F-box and WD-40 domain protein 5, anticorps FBXW5, anticorps Fbxw5
    Sujet

    Background: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.

    Aliases: FBXW5 antibody, FBW5 antibody, PP3971F-box/WD repeat-containing protein 5 antibody, F-box and WD-40 domain-containing protein 5 antibody

    UniProt
    Q969U6
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