FOXN1 anticorps (AA 1-160)

N° du produit ABIN7153070

Cet anticorps Lapin Polyclonal détecte spécifiquement FOXN1 dans WB, ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour FOXN1 anticorps (AA 1-160) (ABIN7153070)

Antigène: FOXN1 (Forkhead Box N1 (FOXN1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FOXN1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-FOXN1 anticorps

Épitope: AA 1-160

Fonction: FOXN1 Antibody

Réactivité croisée: Souris

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Forkhead box protein N1 protein (1-160AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FOXN1

Antigène: FOXN1 (Forkhead Box N1 (FOXN1))

Autre désignation: FOXN1

Sujet:

Background: Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs). Essential for maintenance of mTECs population in the postnatal thymus. Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus. Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age. Essential for the vascularization of the thymus anlage. Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (By similarity). Plays a crucial role in the early prenatal stages of T-cell ontogeny (PubMed:21507891).

Aliases: FKHL20 antibody, Forkhead box N1 antibody, Forkhead box protein N1 antibody, FOXN 1 antibody, FOXN1 antibody, FOXN1_HUMAN antibody, RONU antibody, Rowett nude antibody, Transcription factor winged-helix nude antibody, WHN antibody, Winged helix nude antibody, Winged-helix transcription factor nude antibody

UniProt: O15353