FOXP1 anticorps (AA 541-677)

N° du produit ABIN7153092

Détail du produit anti-FOXP1 anticorps

Antigène: FOXP1 (Forkhead Box P1 (FOXP1))

Épitope: AA 541-677

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FOXP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris, Rat

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Forkhead box protein P1 protein (541-677AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur FOXP1

Antigène: FOXP1 (Forkhead Box P1 (FOXP1))

Autre désignation: FOXP1 (FOXP1 Produits)

Synonymes: anticorps 12CC4, anticorps QRF1, anticorps hFKH1B, anticorps 3110052D19Rik, anticorps 4932443N09Rik, anticorps AI461938, anticorps AW494214, anticorps foxp1, anticorps im:7139058, anticorps wu:fc83a06, anticorps FOXP1, anticorps MGC145686, anticorps 12cc4, anticorps fkh1b, anticorps hspc215, anticorps qrf1, anticorps xlfoxp1, anticorps im:7146611, anticorps wu:fb97f01, anticorps zgc:154010, anticorps forkhead box P1, anticorps forkhead box P1b, anticorps forkhead box P1 S homeolog, anticorps forkhead box P1a, anticorps FOXP1, anticorps Foxp1, anticorps foxp1b, anticorps foxp1, anticorps foxp1.S, anticorps foxp1a

Sujet:

Background: Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program, the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity, may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintainance of hair follicle stem cell quiescence, the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions, repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis, the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093).

Aliases: 12CC4 antibody, FLJ23741 antibody, Fork head related protein like B antibody, Forkhead box P1 antibody, Forkhead box protein P1 antibody, FOX P1 antibody, FOXP 1 antibody, foxp1 antibody, FOXP1_HUMAN antibody, Glutamine rich factor 1 antibody, hFKH1B antibody, HSPC215 antibody, MGC12942 antibody, MGC88572 antibody, MGC99551 antibody, QRF 1 antibody, QRF1 antibody

UniProt: Q9H334

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response