Gasdermin A anticorps (AA 64-172)

N° du produit ABIN7153647

Détail du produit anti-Gasdermin A anticorps

Antigène: Gasdermin A (GSDMA)

Épitope: AA 64-172

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Gasdermin A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Gasdermin-A protein (64-172AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur Gasdermin A

Antigène: Gasdermin A (GSDMA)

Autre désignation: GSDMA (GSDMA Produits)

Synonymes: anticorps BB149167, anticorps Gsdm, anticorps Gsdm1, anticorps Gsdma1, anticorps H312E, anticorps GSDM1, anticorps GSDM, anticorps gasdermin A, anticorps Gsdma, anticorps GSDMA

Sujet:

Background: May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).

Aliases: GSDMA antibody, GSDM antibody, GSDM1 antibody, FKSG9Gasdermin-A antibody, Gasdermin-1 antibody

UniProt: Q96QA5