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GNA12 anticorps (AA 112-270)

GNA12 Reactivité: Humain WB, ELISA, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7154731
  • Antigène Voir toutes GNA12 Anticorps
    GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
    Épitope
    • 15
    • 8
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 112-270
    Reactivité
    • 44
    • 15
    • 15
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    Humain
    Hôte
    • 44
    • 1
    Lapin
    Clonalité
    • 45
    Polyclonal
    Conjugué
    • 16
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GNA12 est non-conjugé
    Application
    • 20
    • 16
    • 13
    • 13
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Guanine nucleotide-binding protein subunit alpha-12 protein (112-270AA)
    Isotype
    IgG
  • Indications d'application
    Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
    Autre désignation
    GNA12 (GNA12 Produits)
    Synonymes
    anticorps NNX3, anticorps RMP, anticorps gep, anticorps gna12, anticorps gna12l, anticorps AI414047, anticorps AI504261, anticorps Galpha12, anticorps G protein subunit alpha 12, anticorps guanine nucleotide binding protein (G protein) alpha 12a, anticorps guanine nucleotide binding protein, alpha 12, anticorps GNA12, anticorps Gna12, anticorps gna12a
    Sujet

    Background: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).

    Aliases: G alpha 12 antibody, G alpha-12 antibody, G-protein subunit alpha-12 antibody, gep antibody, Gna12 antibody, GNA12_HUMAN antibody, guanine nucleotide binding protein (G protein) alpha 12 antibody, Guanine nucleotide binding protein alpha 12 subunit antibody, Guanine nucleotide-binding protein subunit alpha-12 antibody, MGC104623 antibody, MGC99644 antibody, NNX3 antibody, RMP antibody, WUGSC:H_GS165O14.2 antibody

    UniProt
    Q03113
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