HDAC6 anticorps (AA 160-470)

N° du produit ABIN7155322

Cet anticorps anti-HDAC6 est un anticorps Lapin Polyclonal détectant HDAC6 dans IHC et ELISA. Adapté pour Humain.

Aperçu rapide pour HDAC6 anticorps (AA 160-470) (ABIN7155322)

Antigène: HDAC6 (Histone Deacetylase 6 (HDAC6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HDAC6 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-HDAC6 anticorps

Épitope: AA 160-470

Fonction: HDAC6 Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Histone deacetylase 6 protein (160-470AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur HDAC6

Antigène: HDAC6 (Histone Deacetylase 6 (HDAC6))

Autre désignation: HDAC6

Sujet:

Background: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy.

Aliases: CPBHM antibody, FLJ16239 antibody, HD 6 antibody, HD6 antibody, HDAC 6 antibody, HDAC6 antibody, HDAC6_HUMAN antibody, Histone deacetylase 6 (HD6) antibody, Histone deacetylase 6 antibody, JM 21 antibody, JM21 antibody, KIAA0901 antibody, OTTHUMP00000032398 antibody, OTTHUMP00000197663 antibody, PPP1R90 antibody, Protein phosphatase 1 regulatory subunit 90 antibody

UniProt: Q9UBN7

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling