SAP18 anticorps (AA 2-153)

N° du produit ABIN7155341

Cet anticorps Lapin Polyclonal détecte spécifiquement SAP18 dans IHC et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour SAP18 anticorps (AA 2-153) (ABIN7155341)

Antigène: SAP18 (Sin3A-Associated Protein, 18kDa (SAP18))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SAP18 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-SAP18 anticorps

Épitope: AA 2-153

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Histone deacetylase complex subunit SAP18 protein (2-153AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur SAP18

Antigène: SAP18 (Sin3A-Associated Protein, 18kDa (SAP18))

Autre désignation: SAP18

Sujet:

Background: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S), the activity is different from the established EJC assembly and function.

Aliases: 18 kDa Sin3-associated polypeptide antibody, 2HOR0202 antibody, Cell growth-inhibiting gene 38 protein antibody, Histone deacetylase complex subunit SAP18 antibody, SAP18 antibody, SAP18_HUMAN antibody, Sin3-associated polypeptide p18 antibody

UniProt: O00422