MEIS2 anticorps (AA 377-470)

N° du produit ABIN7155786

L’anticorps Lapin Polyclonal anti-MEIS2 a été validé pour WB, ELISA et IF. Il convient pour détecter MEIS2 dans des échantillons de Humain.

Aperçu rapide pour MEIS2 anticorps (AA 377-470) (ABIN7155786)

Antigène: MEIS2 (Meis Homeobox 2 (MEIS2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MEIS2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Détail du produit anti-MEIS2 anticorps

Épitope: AA 377-470

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Homeobox protein Meis2 protein (377-470AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MEIS2

Antigène: MEIS2 (Meis Homeobox 2 (MEIS2))

Autre désignation: MEIS2

Sujet:

Background: Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer, the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element, MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5\\\'-CGGTCA-3\\\', in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5\\\'-TGACAG-3\\\'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription, isoform 5 cannot activate DRD1 transcription.

Aliases: Homeobox protein Meis2 antibody, HsT18361 antibody, Meis (mouse) homolog 2 antibody, Meis homeobox 2 antibody, Meis homolog 2 antibody, Meis1 myeloid ecotropic viral integration site 1 homolog 2 (mouse) antibody, Meis1 myeloid ecotropic viral integration site 1 homolog 2 antibody, Meis1 related gene 1 antibody, Meis1 related protein 1 antibody, Meis1-related protein 1 antibody, MEIS2 antibody, MEIS2_HUMAN antibody, MGC2820 antibody, MRG1 antibody, TALE homeobox protein Meis2 antibody

UniProt: O14770