Human Immunodeficiency Virus Vpx (HIV Vpx) (AA 1-112) anticorps

N° du produit ABIN7156073

Cet anticorps Lapin Polyclonal détecte spécifiquement Human Immunodeficiency Virus Vpx dans ELISA et WB. Il présente une réactivité avec des échantillons de Human Immunodeficiency Virus (HIV).

Aperçu rapide pour Human Immunodeficiency Virus Vpx (HIV Vpx) (AA 1-112) anticorps (ABIN7156073)

Antigène: Human Immunodeficiency Virus Vpx (HIV Vpx)

Reactivité: Human Immunodeficiency Virus (HIV)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: ELISA, Western Blotting (WB)

Détail du produit

Épitope: AA 1-112

Fonction: vpx Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human immunodeficiency virus type 2 subtype A Protein Vpx protein (1-112AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détail du antigène

Antigène: Human Immunodeficiency Virus Vpx (HIV Vpx)

Autre désignation: HIV vpx

Classe de substances: Viral Protein

Sujet:

Background: Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription (By similarity).

Aliases: vpxProtein Vpx antibody, Viral protein X antibody, X ORF protein antibody

UniProt: P06939