KPNA5 anticorps (AA 1-240)

N° du produit ABIN7156130

Cet anticorps Lapin Polyclonal détecte spécifiquement KPNA5 dans WB, ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour KPNA5 anticorps (AA 1-240) (ABIN7156130)

Antigène: KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KPNA5 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-KPNA5 anticorps

Épitope: AA 1-240

Réactivité croisée: Humain, Souris

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Importin subunit alpha-6 protein (1-240AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur KPNA5

Antigène: KPNA5 (Karyopherin alpha 5 (Importin alpha 6) (KPNA5))

Autre désignation: KPNA5

Sujet:

Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Aliases: IMA5_HUMAN antibody, Importin alpha 6 antibody, Importin subunit alpha 6 antibody, Importin subunit alpha-6 antibody, IPOA 6 antibody, IPOA6 antibody, Karyopherin alpha 5 antibody, Karyopherin alpha 5 importin alpha 6 antibody, Karyopherin subunit alpha 5 antibody, Karyopherin subunit alpha-5 antibody, KPNA 5 antibody, KPNA5 antibody, SRP 6 antibody, SRP6 antibody

UniProt: O15131

Pathways: Protein targeting to Nucleus