KPNB1 anticorps (AA 9-214)

N° du produit ABIN7156134

L’anticorps Lapin Polyclonal anti-KPNB1 a été validé pour WB, IHC et ELISA. Il convient pour détecter KPNB1 dans des échantillons de Humain.

Aperçu rapide pour KPNB1 anticorps (AA 9-214) (ABIN7156134)

Antigène: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KPNB1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Détail du produit anti-KPNB1 anticorps

Épitope: AA 9-214

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Importin subunit beta-1 protein (9-214AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:200-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur KPNB1

Antigène: KPNB1 (Karyopherin (Importin) beta 1 (KPNB1))

Autre désignation: KPNB1

Sujet:

Background: Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.

Aliases: IMB 1 antibody, IMB1 antibody, IMB1_HUMAN antibody, Impnb antibody, Importin 90 antibody, Importin beta 1 antibody, Importin beta 1 subunit antibody, Importin subunit beta-1 antibody, Importin-90 antibody, IPOB antibody, Karyopherin beta 1 antibody, Karyopherin beta 1 subunit antibody, Karyopherin subunit beta-1 antibody, KPNB 1 antibody, Kpnb1 antibody, MGC2155 antibody, MGC2156 antibody, MGC2157 antibody, NTF 97 antibody, NTF97 antibody, NTF97/Importin beta antibody, Nuclear factor P97 antibody, Pore targeting complex 97 kDa subunit antibody, PTAC97 antibody

UniProt: Q14974

Pathways: Protein targeting to Nucleus