IL28B anticorps (AA 22-196)

N° du produit ABIN7156612

Détail du produit anti-IL28B anticorps

Antigène: IL28B (Interleukin 28B (Interferon, lambda 3) (IL28B))

Épitope: AA 22-196

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL28B est non-conjugé

Application: ELISA, Immunohistochemistry (IHC)

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Interferon lambda-3 protein (22-196AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur IL28B

Antigène: IL28B (Interleukin 28B (Interferon, lambda 3) (IL28B))

Autre désignation: IFNL3 (IL28B Produits)

Synonymes: anticorps Il28b, anticorps IFL-1, anticorps IL-28B, anticorps INF-alpha, anticorps INF-lambda, anticorps Il28, anticorps IL28B, anticorps IL28C, anticorps interferon, lambda 3, anticorps interferon lambda 3, anticorps Ifnl3, anticorps IFNL3

Sujet:

Background: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Aliases: Cytokine ZCYTO22 antibody, IFN-lambda-3 antibody, IFN-lambda-4 antibody, IL-28B antibody, IL-28C antibody, IL28B antibody, IL28B_HUMAN antibody, IL28C antibody, Interferon lambda-3 antibody, Interferon lambda-4 antibody, interleukin 28B (interferon, lambda 3) antibody, Interleukin 28C antibody, Interleukin-28B antibody, Interleukin-28C antibody

UniProt: Q8IZI9