KLHL20 anticorps (AA 1-200) (Biotin)

N° du produit ABIN7157278

Cet anticorps anti-KLHL20 est un anticorps Lapin Polyclonal détectant KLHL20 dans ELISA. Adapté pour Humain.

Aperçu rapide pour KLHL20 anticorps (AA 1-200) (Biotin) (ABIN7157278)

Antigène: KLHL20 (Kelch-Like 20 (KLHL20))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KLHL20 est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-KLHL20 anticorps (Biotin)

Épitope: AA 1-200

Fonction: KLHL20 Antibody, Biotin conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Kelch-like protein 20 protein (1-200AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur KLHL20

Antigène: KLHL20 (Kelch-Like 20 (KLHL20))

Autre désignation: KLHL20

Sujet:

Background: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis (PubMed:20389280). The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates \'Lys-33\'-linked ubiquitination (PubMed:24768539). Involved in anterograde Golgi to endosome transport by mediating \'Lys-33\'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking (PubMed:24768539). Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (PubMed:21670212). In case of tumor, the BCR(KLHL20) E3 ubiquitin ligase complex is involved in tumor hypoxia: following hypoxia, the BCR(KLHL20)complex mediates ubiquitination and degradation of PML, potentiating HIF-1 signaling and cancer progression (PubMed:21840486).

Aliases: Kelch like ECT2 interacting protein antibody, Kelch like protein 20 antibody, Kelch like protein X antibody, Kelch motif containing protein antibody, Kelch-like ECT2-interacting protein antibody, Kelch-like protein 20 antibody, Kelch-like protein X antibody, KHLHX antibody, KLEIP antibody, KLH20_HUMAN antibody, KLHL20 antibody, KLHLX antibody, RP3-383J4.3 antibody

UniProt: Q9Y2M5