KNG1 anticorps (AA 390-644) (HRP)

N° du produit ABIN7157684

Cet anticorps Lapin Polyclonal détecte spécifiquement KNG1 dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour KNG1 anticorps (AA 390-644) (HRP) (ABIN7157684)

Antigène: KNG1 (Kininogen 1 (KNG1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KNG1 est conjugé à/à la HRP

Application: ELISA

Détail du produit anti-KNG1 anticorps (HRP)

Épitope: AA 390-644

Fonction: KNG1 Antibody, HRP conjugated

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Kininogen-1 protein (390-644AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur KNG1

Antigène: KNG1 (Kininogen 1 (KNG1))

Autre désignation: KNG1

Sujet:

Background: Kininogens are inhibitors of thiol proteases, (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes, (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action), (5) LMW-kininogen inhibits the aggregation of thrombocytes, (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Aliases: Alpha-2-thiol proteinase inhibitor antibody, BDK antibody, BK antibody, Bradykinin antibody, Bradykinin included antibody, Fitzgerald factor antibody, FLAUJEAC FACTOR antibody, High molecular weight kininogen antibody, HMWK antibody, Ile-Ser-Bradykinin antibody, Kallidin I antibody, Kallidin II antibody, KNG antibody, KNG1 antibody, KNG1_HUMAN antibody, Low molecular weight growth-promoting factor antibody, WILLIAMS FACTOR antibody, Williams-Fitzgerald-Flaujeac factor antibody

UniProt: P01042

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process