LRP4 anticorps (AA 1500-1725)

N° du produit ABIN7158575

Détail du produit anti-LRP4 anticorps

Antigène: LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))

Épitope: AA 1500-1725

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LRP4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Low-density lipoprotein receptor-related protein 4 protein (1500-1725AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur LRP4

Antigène: LRP4 (Low Density Lipoprotein Receptor-Related Protein 4 (LRP4))

Autre désignation: LRP4 (LRP4 Produits)

Synonymes: anticorps CLSS, anticorps LRP-4, anticorps LRP10, anticorps MEGF7, anticorps SOST2, anticorps Megf7, anticorps 6430526J12Rik, anticorps D230026E03, anticorps mdig, anticorps LRP4, anticorps lrp10, anticorps megf7, anticorps LDL receptor related protein 4, anticorps low density lipoprotein receptor-related protein 4, anticorps LRP4, anticorps Lrp4, anticorps lrp4

Sujet:

Background: Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes.

Aliases: KIAA0816 antibody, LDLR dan antibody, Low density lipoprotein receptor related protein 4 antibody, Low-density lipoprotein receptor-related protein 4 antibody, LRP-4 antibody, LRP10 antibody, Lrp4 antibody, LRP4_HUMAN antibody, MEGF7 antibody, Multiple epidermal growth factor like domains 7 antibody, Multiple epidermal growth factor-like domains 7 antibody

UniProt: O75096

Pathways: Skeletal Muscle Fiber Development