BRCC3 anticorps (AA 1-316)

N° du produit ABIN7158678

L’anticorps Lapin Polyclonal anti-BRCC3 a été validé pour WB, ELISA et IHC. Il convient pour détecter BRCC3 dans des échantillons de Humain.

Aperçu rapide pour BRCC3 anticorps (AA 1-316) (ABIN7158678)

Antigène: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRCC3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-BRCC3 anticorps

Épitope: AA 1-316

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Lys-63-specific deubiquitinase BRCC36 protein (1-316AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur BRCC3

Antigène: BRCC3 (BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))

Autre désignation: BRCC3

Sujet:

Background: Metalloprotease that specifically cleaves \\\'Lys-63\\\'-linked polyubiquitin chains. Does not have activity toward \\\'Lys-48\\\'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes \\\'Lys-63\\\'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes \\\'Lys-63\\\'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves \\\'Lys-63\\\'-linked ubiquitin in various substrates. Mediates the specific \\\'Lys-63\\\'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.

Aliases: BRCA1-A complex subunit BRCC36 antibody, BRCA1/BRCA2 containing complex subunit 3 antibody, BRCA1/BRCA2 containing complex subunit 36 antibody, BRCA1/BRCA2-containing complex subunit 3 antibody, BRCA1/BRCA2-containing complex subunit 36 antibody, Brcc3 antibody, BRCC3_HUMAN antibody, BRCC36 antibody, BRISC complex subunit BRCC36 antibody, C6.1A antibody, Chromosome X open reading frame 53 antibody, CXorf53 antibody, Lys-63-specific deubiquitinase BRCC36 antibody, OTTHUMP00000061450 antibody

UniProt: P46736

Pathways: Positive Regulation of Response to DNA Damage Stimulus