MCTS1 anticorps (AA 1-181)

N° du produit ABIN7158949

Détail du produit anti-MCTS1 anticorps

Antigène: MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))

Épitope: AA 1-181

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCTS1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Malignant T-cell-amplified sequence 1 protein (1-181AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:200-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MCTS1

Antigène: MCTS1 (Malignant T Cell Amplified Sequence 1 (MCTS1))

Autre désignation: MCTS1 (MCTS1 Produits)

Synonymes: anticorps MCT-1, anticorps MCT1, anticorps MCT1a, anticorps cb517, anticorps zgc:55682, anticorps 1500019M23Rik, anticorps zgc:56242, anticorps mcts1, anticorps MGC89874, anticorps MCTS1, anticorps MCT-1A, anticorps mct-1, anticorps mct1, anticorps MCT-1B, anticorps mcts1-a, anticorps mcts1-b, anticorps MCTS1, re-initiation and release factor, anticorps solute carrier family 16 (monocarboxylate transporter), member 1b, anticorps malignant T cell amplified sequence 1, anticorps malignant T-cell amplified sequence 1, anticorps solute carrier family 16 member 1, anticorps malignant T-cell amplified sequence 1 S homeolog, anticorps monocarboxylate transporter 1, anticorps malignant T-cell amplified sequence 1 L homeolog, anticorps MCTS1, anticorps slc16a1b, anticorps Mcts1, anticorps mcts1, anticorps SLC16A1, anticorps mcts1.S, anticorps MCT1, anticorps mcts1.L

Sujet:

Background: Anti-oncogene that play a role in cell cycle regulation, decreases cell doubling time and anchorage-dependent growth, shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation, promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer, recruits the density-regulated protein/DENR and binds to the cap complex of the 5\'-terminus of mRNAs, subsequently altering the mRNA translation profile, up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway, increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell, Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation, promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

Aliases: FLJ39637 antibody, Malignant T cell amplified sequence 1 antibody, Malignant T cell-amplified sequence 1 antibody, MCT 1 antibody, MCT-1 antibody, MCT1 antibody, MCTS 1 antibody, MCTS1 antibody, MCTS1_HUMAN antibody, Multiple copies T cell malignancies 1 antibody, Multiple copies T cell malignancies antibody, Multiple copies T-cell malignancies antibody, Oncogene MCT 1 antibody, Oncogene MCT1 antibody

UniProt: Q9ULC4