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PLD6 anticorps (AA 1-252)

PLD6 Reactivité: Humain ELISA, WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN7159837
  • Antigène Voir toutes PLD6 Anticorps
    PLD6 (Phospholipase D Family, Member 6 (PLD6))
    Épitope
    • 9
    • 7
    • 7
    • 6
    • 5
    • 1
    • 1
    AA 1-252
    Reactivité
    • 18
    • 10
    Humain
    Hôte
    • 22
    Lapin
    Clonalité
    • 22
    Polyclonal
    Conjugué
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    Cet anticorp PLD6 est non-conjugé
    Application
    • 18
    • 16
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
     Réactivité croisée
    Humain, Souris
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human Mitochondrial cardiolipin hydrolase protein (1-252AA)
    Isotype
    IgG
    Top Product
    Discover our top product PLD6 Anticorps primaire
  • Indications d'application
    Recommended dilution: WB:1:2000-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    PLD6 (Phospholipase D Family, Member 6 (PLD6))
    Autre désignation
    PLD6 (PLD6 Produits)
    Synonymes
    anticorps ZUC, anticorps 4933433K01Rik, anticorps Gm10, anticorps Zuc, anticorps mZuc, anticorps mitoPLD, anticorps pld6, anticorps fc55d08, anticorps wu:fc55d08, anticorps phospholipase D family member 6, anticorps phospholipase D family, member 6, anticorps phospholipase D family member 6 S homeolog, anticorps PLD6, anticorps Pld6, anticorps pld6.S, anticorps pld6
    Sujet

    Background: Endonuclease that plays a critical role in PIWI-interacting RNA (piRNA) biogenesis during spermatogenesis. piRNAs provide essential protection against the activity of mobile genetic elements (By similarity). piRNA-mediated transposon silencing is thus critical for maintaining genome stability, in particular in germline cells when transposons are mobilized as a consequence of wide-spread genomic demethylation (By similarity). Has been proposed to act as a cardiolipin hydrolase to generate phosphatidic acid at mitochondrial surface (By similarity). Although it cannot be excluded that it can act as a phospholipase in some circumstances, it should be noted that cardiolipin hydrolase activity is either undetectable in vitro, or very low (PubMed:21397848). In addition, cardiolipin is almost exclusively found on the inner mitochondrial membrane, while PLD6 localizes to the outer mitochondrial membrane, facing the cytosol (PubMed:21397848). Has been shown to be a backbone-non-specific, single strand-specific nuclease, cleaving either RNA or DNA substrates with similar affinity. Produces 5\' phosphate and 3\' hydroxyl termini, suggesting it could directly participate in the processing of primary piRNA transcripts (By similarity). Also acts as a regulator of mitochondrial shape through facilitating mitochondrial fusion (PubMed:17028579, PubMed:26711011).

    Aliases: Choline phosphatase 6 antibody, Mitochondrial cardiolipin hydrolase antibody, Mitochondrial phospholipase antibody, MitoPLD antibody, Phosphatidylcholine hydrolyzing phospholipase D6 antibody, Phosphatidylcholine-hydrolyzing phospholipase D6 antibody, Phospholipase D family member 6 antibody, Phospholipase D6 antibody, PLD 6 antibody, pld6 antibody, PLD6_HUMAN antibody, Protein zucchini homolog antibody, ZUC antibody, Zucchini, Drosophila, homolog of antibody

    UniProt
    Q8N2A8
    Pathways
    Ribonucleoprotein Complex Subunit Organization
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