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NDFIP1 anticorps (AA 2-116) (Biotin)

NDFIP1 Reactivité: Humain ELISA Hôte: Lapin Polyclonal Biotin
N° du produit ABIN7161119
  • Antigène Voir toutes NDFIP1 Anticorps
    NDFIP1 (Nedd4 Family Interacting Protein 1 (NDFIP1))
    Épitope
    • 7
    • 7
    • 6
    • 6
    • 6
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    AA 2-116
    Reactivité
    • 39
    • 15
    • 10
    Humain
    Hôte
    • 37
    • 3
    • 1
    • 1
    Lapin
    Clonalité
    • 39
    • 3
    Polyclonal
    Conjugué
    • 17
    • 5
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp NDFIP1 est conjugé à/à la Biotin
    Application
    • 25
    • 23
    • 8
    • 5
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    ELISA
     Réactivité croisée
    Humain
    Purification
    >95%, Protein G purified
    Immunogène
    Recombinant Human NEDD4 family-interacting protein 1 protein (2-116AA)
    Isotype
    IgG
    Top Product
    Discover our top product NDFIP1 Anticorps primaire
  • Indications d'application
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C,-80 °C
    Stockage commentaire
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Antigène
    NDFIP1 (Nedd4 Family Interacting Protein 1 (NDFIP1))
    Autre désignation
    NDFIP1 (NDFIP1 Produits)
    Synonymes
    anticorps zgc:55546, anticorps wu:fc17e11, anticorps n4wbp5, anticorps MGC108163, anticorps ndfip1, anticorps NDFIP1, anticorps N4WBP5, anticorps 0610010M22Rik, anticorps N4wbp5, anticorps Nedd4 family interacting protein 1, anticorps Nedd4 WW domain-binding protein 5, anticorps ndfip1, anticorps NDFIP1, anticorps n4wbp5, anticorps Ndfip1
    Sujet

    Background: Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity (PubMed:19706893). Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate (PubMed:20534535). Enhances the ubiquitination of BRAT1 mediated by E3 ubiquitin-protein ligases: NEDD4, NEDD4L and ITCH, and is required for the nuclear localization of ubiquitinated BRAT1 (PubMed:25631046).

    Aliases: 0610010M22Rik antibody, Breast cancer associated protein SGA 1M antibody, Breast cancer-associated protein SGA-1M antibody, MGC10924 antibody, N4WBP5 antibody, Ndfip1 antibody, Nedd4 family interacting protein 1 antibody, NEDD4 family-interacting protein 1 antibody, NEDD4 WW domain binding protein 5 antibody, NEDD4 WW domain-binding protein 5 antibody, NFIP1_HUMAN antibody, Putative MAPK activating protein PM13 antibody, Putative MAPK-activating protein PM13 antibody, Putative NF kappa B activating protein 164 antibody, Putative NF-kappa-B-activating protein 164 antibody, Putative NFKB and MAPK activating protein antibody, Putative NFKB and MAPK-activating protein antibody

    UniProt
    Q9BT67
    Pathways
    Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Negative Regulation of Transporter Activity
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