NUPR1 anticorps (AA 2-64)

N° du produit ABIN7161848

Cet anticorps Lapin Polyclonal détecte spécifiquement NUPR1 dans ELISA, IHC et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour NUPR1 anticorps (AA 2-64) (ABIN7161848)

Antigène: NUPR1 (Nuclear Protein, Transcriptional Regulator, 1 (NUPR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUPR1 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-NUPR1 anticorps

Épitope: AA 2-64

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Nuclear protein 1 protein (2-64AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NUPR1

Antigène: NUPR1 (Nuclear Protein, Transcriptional Regulator, 1 (NUPR1))

Autre désignation: NUPR1

Sujet:

Background: Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 \'Lys-16\' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.

Aliases: Candidate of metastasis 1 antibody, COM1 antibody, Nuclear protein 1 antibody, Nupr1 antibody, NUPR1_HUMAN antibody, p8 protein antibody, Protein p8 antibody

UniProt: O60356