NUPR1 anticorps (AA 2-64)
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- Antigène Voir toutes NUPR1 Anticorps
- NUPR1 (Nuclear Protein, Transcriptional Regulator, 1 (NUPR1))
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Épitope
- AA 2-64
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp NUPR1 est non-conjugé
- Application
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Réactivité croisée
- Humain
- Purification
- >95%, Protein G purified
- Immunogène
- Recombinant Human Nuclear protein 1 protein (2-64AA)
- Isotype
- IgG
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- Indications d'application
- Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- NUPR1 (Nuclear Protein, Transcriptional Regulator, 1 (NUPR1))
- Autre désignation
- NUPR1 (NUPR1 Produits)
- Synonymes
- anticorps COM1, anticorps P8, anticorps 2310032H04Rik, anticorps Com1, anticorps p8, anticorps nuclear protein 1, transcriptional regulator, anticorps nuclear protein transcription regulator 1, anticorps NUPR1, anticorps Nupr1
- Sujet
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Background: Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 \'Lys-16\' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.
Aliases: Candidate of metastasis 1 antibody, COM1 antibody, Nuclear protein 1 antibody, Nupr1 antibody, NUPR1_HUMAN antibody, p8 protein antibody, Protein p8 antibody
- UniProt
- O60356
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