RORB anticorps (AA 1-269)

N° du produit ABIN7161877

Détail du produit anti-RORB anticorps

Antigène: RORB (RAR-Related Orphan Receptor B (RORB))

Épitope: AA 1-269

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RORB est non-conjugé

Application: Western Blotting (WB), ELISA

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Nuclear receptor ROR-beta protein (1-269AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:2000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RORB

Antigène: RORB (RAR-Related Orphan Receptor B (RORB))

Autre désignation: RORB (RORB Produits)

Synonymes: anticorps RORB, anticorps Nr1f2, anticorps LOC100226267, anticorps NR1F2, anticorps ROR-BETA, anticorps RZR-BETA, anticorps RZRB, anticorps bA133M9.1, anticorps nr1f2, anticorps rzrb, anticorps sb:eu943, anticorps RZR-beta, anticorps Rorbeta, anticorps RAR related orphan receptor B, anticorps RAR-related orphan receptor B, anticorps RAR-related orphan receptor beta, anticorps RORB, anticorps Rorb, anticorps rorb

Sujet:

Background: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5\'-AGGTCA-3\' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity).

Aliases: bA133M9.1 antibody, NR1F2 antibody, Nuclear receptor ROR-beta antibody, Nuclear receptor RZR beta antibody, Nuclear receptor RZR-beta antibody, Nuclear receptor subfamily 1 group F member 2 antibody, OTTHUMP00000021486 antibody, RAR related orphan receptor B antibody, RAR related orphan receptor beta antibody, Retinoic acid binding receptor beta antibody, Retinoid-related orphan receptor-beta antibody, ROR BETA antibody, Rorb antibody, RORB_HUMAN antibody, RZR BETA antibody, RZRB antibody

UniProt: Q92753

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway