NME4 anticorps (AA 1-187)

N° du produit ABIN7162056

L’anticorps Lapin Polyclonal anti-NME4 a été validé pour IHC et ELISA. Il convient pour détecter NME4 dans des échantillons de Humain.

Aperçu rapide pour NME4 anticorps (AA 1-187) (ABIN7162056)

Antigène: NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4 (NME4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NME4 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-NME4 anticorps

Épitope: AA 1-187

Réactivité croisée: Humain

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Nucleoside diphosphate kinase, mitochondrial protein (1-187AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur NME4

Antigène: NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4 (NME4))

Autre désignation: NME4

Sujet:

Background: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin, the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK, its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663).

Aliases: metastatic inhibition factor NM23H4 antibody, mitochondrial antibody, NDK antibody, NDKM_HUMAN antibody, NDP kinase antibody, NDP kinase D antibody, NDP kinase, mitochondrial antibody, NDPK D antibody, NDPKD antibody, nm23 H4 antibody, nm23-H4 antibody, NM23D antibody, NM23H4 antibody, Nm23M4 antibody, NME/NM23 nucleoside diphosphate kinase 4 antibody, NME4 antibody, Non metastatic cells 4 protein expressed in antibody, Non metastatic protein 23, homolog 4 antibody, Nucleoside diphosphate kinase D antibody, Nucleoside diphosphate kinase, mitochondrial antibody, Nucleoside diphosphate kinase, mitochondrial antibody

UniProt: O00746

Pathways: Nucleotide Phosphorylation, Ribonucleoside Biosynthetic Process