OTUD7B anticorps (AA 235-347)

N° du produit ABIN7162338

L’anticorps Lapin Polyclonal anti-OTUD7B a été validé pour ELISA, IHC et IF. Il convient pour détecter OTUD7B dans des échantillons de Humain.

Aperçu rapide pour OTUD7B anticorps (AA 235-347) (ABIN7162338)

Antigène: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OTUD7B est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-OTUD7B anticorps

Épitope: AA 235-347

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human OTU domain-containing protein 7B protein (235-347AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur OTUD7B

Antigène: OTUD7B (OTU Domain Containing 7B (OTUD7B))

Autre désignation: OTUD7B

Sujet:

Background: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses. In response to non-canonical NF-kappa-B stimuli, deubiquitinates \\\'Lys-48\\\'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B. Negatively regulates mucosal immunity against infections (By similarity). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (By similarity). Mediates deubiquitination of EGFR (PubMed:22179831). Has deubiquitinating activity toward \\\'Lys-11\\\', \\\'Lys-48\\\' and \\\'Lys-63\\\'-linked polyubiquitin chains (PubMed:27732584). Has a much higher catalytic rate with \\\'Lys-11\\\'-linked polyubiquitin chains (in vitro), however the physiological significance of these data are unsure (PubMed:27732584). Hydrolyzes both linear and branched forms of polyubiquitin.

Aliases: Cellular zinc finger anti NF kappa B protein antibody, Cellular zinc finger anti-NF-kappa-B protein antibody, CEZANNE antibody, HGNC:16683 antibody, OTU domain containing protein 7B antibody, OTU domain-containing protein 7B antibody, OTU7B_HUMAN antibody, OTUD7B antibody, ZA20D1 antibody, Zinc finger A20 domain containing protein 1 antibody, Zinc finger A20 domain-containing protein 1 antibody, Zinc finger protein Cezanne antibody

UniProt: Q6GQQ9