PIWIL1 anticorps (AA 390-690)

N° du produit ABIN7163477

Cet anticorps Lapin Polyclonal détecte spécifiquement PIWIL1 dans IHC et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour PIWIL1 anticorps (AA 390-690) (ABIN7163477)

Antigène: PIWIL1 (Piwi-Like 1 (PIWIL1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIWIL1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Détail du produit anti-PIWIL1 anticorps

Épitope: AA 390-690

Fonction: PIWIL1 Antibody

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Piwi-like protein 1 protein (390-690AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PIWIL1

Antigène: PIWIL1 (Piwi-Like 1 (PIWIL1))

Autre désignation: PIWIL1

Sujet:

Background: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability (By similarity). Isoform 3 may be a negative developmental regulator (PubMed:12037681, PubMed:16287078).

Aliases: HIWI antibody, MIWI antibody, Piwi (Drosophila) like 1 antibody, PIWI antibody, Piwi homolog antibody, Piwi like 1 (drosophila) antibody, Piwi like 1 antibody, Piwi-like protein 1 antibody, PIWIL1 antibody, PIWL1_HUMAN antibody

UniProt: Q96J94