PARG anticorps (AA 1-348)

N° du produit ABIN7163765

Cet anticorps Lapin Polyclonal détecte spécifiquement PARG dans ELISA et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour PARG anticorps (AA 1-348) (ABIN7163765)

Antigène: PARG

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PARG est non-conjugé

Application: ELISA, Immunofluorescence (IF)

Détail du produit anti-PARG anticorps

Épitope: AA 1-348

Fonction: PARG Antibody

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Poly(ADP-ribose) glycohydrolase protein (1-348AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PARG

Antigène: PARG

Autre désignation: PARG

Sujet:

Background: Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP-ribose monomers (PubMed:23102699). Required for retinoid acid-dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression at RAR-dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257).

Aliases: ADP riboseglycohydrolase antibody, Mitochondrial poly(ADP ribose) glycohydrolase antibody, Parg antibody, PARG_HUMAN antibody, PARG99 antibody, Poly antibody, poly (ADP ribose) glycohydrolase antibody, poly(ADP-ribose) glycohydrolase 60 kDa isoform antibody, Poly(ADP-ribose) glycohydrolase antibody

UniProt: Q86W56