PBX1 anticorps (AA 315-430)

N° du produit ABIN7164137

Cet anticorps Lapin Polyclonal détecte spécifiquement PBX1 dans WB, ELISA, IF et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour PBX1 anticorps (AA 315-430) (ABIN7164137)

Antigène: PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PBX1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Détail du produit anti-PBX1 anticorps

Épitope: AA 315-430

Fonction: PBX1 Antibody

Réactivité croisée: Rat

Purification: Protein G purified

Pureté: >95 %

Immunogène: Recombinant Human Pre-B-cell leukemia transcription factor 1 protein (315-430AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PBX1

Antigène: PBX1 (Pre-B-Cell Leukemia Homeobox Protein 1 (PBX1))

Autre désignation: PBX1

Sujet:

Background: Binds the sequence 5\\\'-ATCAATCAA-3\\\'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1,19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer, the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity).

Aliases: DKFZp686B09108 antibody, Homeo box protein PBX1 antibody, Homeo box protein PRL antibody, Homeobox protein PBX 1 antibody, Homeobox protein PBX1 antibody, Homeobox protein PRL antibody, MGC126627 antibody, PBX 1 antibody, Pbx1 antibody, PBX1_HUMAN antibody, Pre B cell leukemia homeobox 1 antibody, Pre B cell leukemia transcription factor 1 antibody, Pre-B-cell leukemia transcription factor 1 antibody, PRL antibody

UniProt: P40424