PSTPIP1 anticorps (AA 157-416)

N° du produit ABIN7164772

Cet anticorps anti-PSTPIP1 est un anticorps Lapin Polyclonal détectant PSTPIP1 dans WB, ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour PSTPIP1 anticorps (AA 157-416) (ABIN7164772)

Antigène: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSTPIP1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-PSTPIP1 anticorps

Épitope: AA 157-416

Réactivité croisée: Humain, Souris

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Proline-serine-threonine phosphatase-interacting protein 1 protein (157-416AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PSTPIP1

Antigène: PSTPIP1 (Proline-serine-threonine Phosphatase Interacting Protein 1 (PSTPIP1))

Autre désignation: PSTPIP1

Sujet:

Background: Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.

Aliases: CD2 antigen binding protein 1 antibody, CD2 binding protein 1 antibody, CD2 cytoplasmic tail binding protein antibody, CD2-binding protein 1 antibody, CD2BP1 antibody, CD2BP1L antibody, CD2BP1S antibody, H PIP antibody, H-PIP antibody, HPIP antibody, PAPAS antibody, PEST phosphatase interacting protein 1 antibody, PEST phosphatase-interacting protein 1 antibody, PPIP1_HUMAN antibody, Proline serine threonine phosphatase interacting protein 1 antibody, Proline-serine-threonine phosphatase-interacting protein 1 antibody, PSTPIP antibody, Pstpip1 antibody

UniProt: O43586