PRMT1 anticorps (AA 1-248)

N° du produit ABIN7165056

Détail du produit anti-PRMT1 anticorps

Antigène: PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))

Épitope: AA 1-248

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PRMT1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Protein arginine N-methyltransferase 1 protein (1-248AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur PRMT1

Antigène: PRMT1 (Protein Arginine Methyltransferase 1 (PRMT1))

Autre désignation: PRMT1 (PRMT1 Produits)

Synonymes: anticorps ANM1, anticorps HCP1, anticorps HRMT1L2, anticorps IR1B4, anticorps 6720434D09Rik, anticorps AW214366, anticorps Hrmt1l2, anticorps Mrmt1, anticorps 3E10, anticorps anm1, anticorps hcp1, anticorps hrmt1l2, anticorps ir1b4, anticorps prmt1, anticorps prmt1b, anticorps xPRMT1b, anticorps xprmt1, anticorps xPRMT1, anticorps ARABIDOPSIS THALIANA PROTEIN ARGININE METHYLTRANSFERASE 1A, anticorps ATPRMT1A, anticorps F6F22.30, anticorps F6F22_30, anticorps protein arginine methyltransferase 1A, anticorps DDBDRAFT_0183976, anticorps DDBDRAFT_0235399, anticorps DDB_0183976, anticorps DDB_0235399, anticorps PRMT1, anticorps DKFZp459J1326, anticorps fb39h07, anticorps wu:fb39h07, anticorps zf1, anticorps zgc:66201, anticorps protein arginine methyltransferase 1, anticorps protein arginine N-methyltransferase 1, anticorps protein arginine methyltransferase 1 L homeolog, anticorps protein arginine methyltransferase 1 S homeolog, anticorps protein arginine methyltransferase 1A, anticorps protein arginine N-methyltransferase-1, anticorps protein arginine N-methyltransferase, anticorps protein arginine methyltransferase, anticorps PRMT1, anticorps Prmt1, anticorps prmt1.L, anticorps prmt1.S, anticorps PRMT1A, anticorps prm-1, anticorps EDI_007800, anticorps Smp_029240.3, anticorps prmt1

Sujet:

Background: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:16879614, PubMed:26876602). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 \\\'Arg-4\\\' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).

Aliases: ANM 1 antibody, ANM1 antibody, ANM1_HUMAN antibody, HCP 1 antibody, HCP1 antibody, Heterogeneous nuclear ribonucleoprotein methyltransferase 1 like 2 antibody, Heterogeneous nuclear ribonucleoproteins methyltransferase like 2 antibody, Heterogeneous nuclear ribonucleoproteins methyltransferase like2 antibody, Histone-arginine N-methyltransferase PRMT1 antibody, HMT 2 antibody, HMT1 (hnRNP methyltransferase S. cerevisiae) like 2 antibody, HMT1 hnRNP methyltransferase antibody, HMT1 hnRNP methyltransferase like 2 (S. cerevisiae) antibody, HMT1 hnRNP methyltransferase like 2 antibody, HMT2 antibody, HRMT1 L2 antibody, HRMT1L 2 antibody, HRMT1L2 antibody, Human mRNA for suppressor for yeast mutant antibody, Human mRNA for suppressor for yeast mutant complete cds antibody, Interferon receptor 1 bound protein 4 antibody, Interferon receptor 1 bound protein4 antibody, Interferon receptor 1-bound protein 4 antibody, Interferon receptor 1bound protein 4 antibody, IR1 B4 antibody, IR1B 4 antibody, IR1B4 antibody, Mrmt 1 antibody, Mrmt1 antibody, PRMT 1 antibody, PRMT1 antibody, Protein arginine methyltransferase 1 antibody, Protein arginine N methyltransferase 1 antibody, Protein arginine N methyltransferase1 antibody, Protein arginine N-methyltransferase 1 antibody, R1B4 antibody, S. cerevisiae like 2 antibody

UniProt: Q99873