MAGOH anticorps (AA 1-146)

N° du produit ABIN7165791

L’anticorps Lapin Polyclonal anti-MAGOH a été validé pour WB, ELISA, IHC et IP. Il convient pour détecter MAGOH dans des échantillons de Humain.

Aperçu rapide pour MAGOH anticorps (AA 1-146) (ABIN7165791)

Antigène: MAGOH (Mago-Nashi Homolog (MAGOH))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAGOH est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Détail du produit anti-MAGOH anticorps

Épitope: AA 1-146

Fonction: MAGOH Antibody

Réactivité croisée: Souris

Purification: Antigen Affinity Purified

Immunogène: Recombinant Human Protein mago nashi homolog protein (1-146AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur MAGOH

Antigène: MAGOH (Mago-Nashi Homolog (MAGOH))

Autre désignation: MAGOH

Sujet:

Background: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the function is different from the established EJC assembly.

Aliases: Mago nashi homolog proliferation associated (Drosophila) antibody, Mago nashi protein homolog antibody, magoh antibody, MAGOHA antibody, MGN_HUMAN antibody, Protein mago nashi homolog antibody

UniProt: P61326