CoREST anticorps (AA 394-482) (Biotin)

N° du produit ABIN7167722

Cet anticorps Lapin Polyclonal détecte spécifiquement CoREST dans ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour CoREST anticorps (AA 394-482) (Biotin) (ABIN7167722)

Antigène: CoREST (RCOR1) (REST Corepressor 1 (RCOR1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CoREST est conjugé à/à la Biotin

Application: ELISA

Détail du produit anti-CoREST anticorps (Biotin)

Épitope: AA 394-482

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human REST corepressor 1 protein (394-482AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur CoREST

Antigène: CoREST (RCOR1) (REST Corepressor 1 (RCOR1))

Autre désignation: RCOR1

Sujet:

Background: Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.

Aliases: COREST antibody, KIAA0071 antibody, Nr2b2 antibody, Nuclear receptor coregulator 1 antibody, Nuclear receptor subfamily 2 group B member 2 antibody, Protein CoREST antibody, RCOR antibody, Rcor1 antibody, RCOR1_HUMAN antibody, REST corepressor 1 antibody, Retinoic acid receptor RXR-beta antibody, Retinoid X receptor beta antibody, Rxrb antibody

UniProt: Q9UKL0

Pathways: Regulation of Hormone Metabolic Process, Chromatin Binding