RNF11 anticorps (AA 1-154)
Aperçu rapide pour RNF11 anticorps (AA 1-154) (ABIN7168238)
Antigène
Voir toutes RNF11 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- AA 1-154
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Fonction
- RNF11 Antibody
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Purification
- Antigen Affinity Purified
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Immunogène
- Recombinant Human RING finger protein 11 protein (1-154AA)
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Isotype
- IgG
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C,-80 °C
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Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- RNF11 (Ring Finger Protein 11 (RNF11))
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Autre désignation
- RNF11
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Sujet
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Background: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates \\\'Lys-63\\\' polyubiquitin chains on RIPK1 and catalyzes the formation of \\\'Lys-48\\\'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
Aliases: CGI 123 antibody, RING finger protein 11 antibody, RNF11 antibody, RNF11_HUMAN antibody, Sid 1669 antibody, SID1669 antibody
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UniProt
- Q9Y3C5
Antigène
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