RBM4 anticorps (AA 121-205)

N° du produit ABIN7168345

Cet anticorps anti-RBM4 est un anticorps Lapin Polyclonal détectant RBM4 dans WB, ELISA et IHC. Adapté pour Humain.

Aperçu rapide pour RBM4 anticorps (AA 121-205) (ABIN7168345)

Antigène: RBM4 (RNA Binding Motif Protein 4 (RBM4))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RBM4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-RBM4 anticorps

Épitope: AA 121-205

Réactivité croisée: Humain, Souris

Purification: >95%, Protein G purified

Immunogène: Recombinant Human RNA-binding protein 4 protein (121-205AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RBM4

Antigène: RBM4 (RNA Binding Motif Protein 4 (RBM4))

Autre désignation: RBM4

Sujet:

Background: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5\\\'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3\\\'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3\\\'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5\\\'-CGCGCG[GCA]-3\\\' motif in vitro.

Aliases: dkfzp547k0918 antibody, hLark antibody, lark antibody, Lark homolog antibody, lark homologue antibody, mgc75138 antibody, RBM4 antibody, rbm4 lark antibody, RBM4_HUMAN antibody, RNA binding motif 4 antibody, RNA binding motif 4a antibody, RNA-binding motif protein 4 antibody, RNA-binding motif protein 4a antibody, RNA-binding protein 4 antibody

UniProt: Q9BWF3

Pathways: Regulation of Muscle Cell Differentiation, Photoperiodism