RC3H2 anticorps (AA 251-506)

N° du produit ABIN7168432

Détail du produit anti-RC3H2 anticorps

Antigène: RC3H2 (Membrane Associated DNA Binding Protein (RC3H2))

Épitope: AA 251-506

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RC3H2 est non-conjugé

Application: ELISA

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Roquin-2 protein (251-506AA)

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur RC3H2

Antigène: RC3H2 (Membrane Associated DNA Binding Protein (RC3H2))

Autre désignation: RC3H2 (RC3H2 Produits)

Synonymes: anticorps Mnab, anticorps MNAB, anticorps RNF164, anticorps 2900024N03Rik, anticorps 9430019J22Rik, anticorps D930043C02Rik, anticorps Rnf164, anticorps ring finger and CCCH-type domains 2, anticorps ring finger and CCCH-type zinc finger domains 2, anticorps Rc3h2, anticorps RC3H2

Sujet:

Background: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3\'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation. May act as a ubiquitin E3 ligase. Involved in the ubiquitination of MAP3K5 (PubMed:24448648).

Aliases: 2900024N03Rik antibody, 9430019J22Rik antibody, D930043C02Rik antibody, FLJ20301 antibody, FLJ20713 antibody, Membrane associated DNA binding protein antibody, Membrane associated nucleic acid binding protein antibody, Membrane-associated nucleic acid-binding protein antibody, MGC52176 antibody, MNAB antibody, OTTHUMP00000022076 antibody, OTTHUMP00000022077 antibody, OTTMUSP00000013545 antibody, OTTMUSP00000013546 antibody, Rc3h2 antibody, RC3H2_HUMAN antibody, Ring finger and CCCH type domains 2 antibody, RING finger and CCCH type zinc finger domain containing protein 2 antibody, Ring finger and CCCH-type zinc finger domain-containing protein 2 antibody, ring finger and CCCH-type zinc finger domains 2 antibody, RING finger protein 164 antibody, RNF164 antibody, roquin-2 antibody, RP23-321B3.1 antibody

UniProt: Q9HBD1