Seryl-tRNA Synthetase (SARS) (AA 2-233) anticorps

N° du produit ABIN7168949

Cet anticorps Lapin Polyclonal détecte spécifiquement dans WB, ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour Seryl-tRNA Synthetase (SARS) (AA 2-233) anticorps (ABIN7168949)

Antigène: Seryl-tRNA Synthetase (SARS)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit

Épitope: AA 2-233

Réactivité croisée: Humain

Purification: >95%, Protein G purified

Immunogène: Recombinant Human Serine--tRNA ligase, cytoplasmic protein (2-233AA)

Isotype: IgG

Information d'application

Indications d'application: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détail du antigène

Antigène: Seryl-tRNA Synthetase (SARS)

Autre désignation: SARS

Sujet:

Background: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at \\\'Lys-16\\\' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).

Aliases: C78314 antibody, cytoplasmic antibody, EC 6.1.1.11 antibody, FLJ36399 antibody, sarS antibody, Sars1 antibody, Serine tRNA ligase 1, cytoplasmic antibody, Serine tRNA ligase antibody, Serine--tRNA ligase antibody, serine--tRNA ligase, cytoplasmic antibody, SerRS antibody, SERS antibody, Seryl tRNA Ser/Sec synthetase antibody, Seryl tRNA synthetase antibody, Seryl tRNA synthetase cytoplasmic antibody, Seryl-tRNA Ser/Sec synthetase antibody, Seryl-tRNA synthetase antibody, seryl-tRNA synthetase, cytoplasmic antibody, Seryl-tRNA(Ser/Sec) synthetase antibody, Strs antibody, SYSC_HUMAN antibody

UniProt: P49591