STRAP anticorps (AA 1-350)
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- Antigène Voir toutes STRAP Anticorps
- STRAP (Serine/threonine Kinase Receptor Associated Protein (STRAP))
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Épitope
- AA 1-350
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp STRAP est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- Réactivité croisée
- Humain, Souris
- Purification
- Antigen Affinity Purified
- Immunogène
- Recombinant Human Serine-threonine kinase receptor-associated protein (1-350AA)
- Isotype
- IgG
- Top Product
- Discover our top product STRAP Anticorps primaire
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- Indications d'application
- Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C,-80 °C
- Stockage commentaire
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Antigène
- STRAP (Serine/threonine Kinase Receptor Associated Protein (STRAP))
- Autre désignation
- STRAP (STRAP Produits)
- Synonymes
- anticorps MAWD, anticorps PT-WD, anticorps UNRIP, anticorps zgc:56677, anticorps zgc:77604, anticorps mawd, anticorps pt-wd, anticorps unrip, anticorps AW557906, anticorps C78091, anticorps C79202, anticorps Unrip, anticorps serine/threonine kinase receptor associated protein, anticorps tetratricopeptide repeat domain 5, anticorps serine/threonine kinase receptor associated protein L homeolog, anticorps serine/threonine kinase receptor associated protein S homeolog, anticorps STRAP, anticorps TTC5, anticorps strap, anticorps strap.L, anticorps strap.S, anticorps Strap
- Sujet
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Background: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.
Aliases: MAP activator with WD repeats antibody, MAWD antibody, PTWD antibody, Serine-threonine kinase receptor-associated protein antibody, serine/threonine kinase receptor associated protein antibody, strap antibody, STRAP_HUMAN antibody, UNR-interacting protein antibody, UNRIP antibody, WD 40 repeat protein PT WD antibody, WD-40 repeat protein PT-WD antibody
- UniProt
- Q9Y3F4
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